Understanding Mechanisms

Our long-term goal is to understand the mechanisms responsible for adult and pediatric cancers progression and to develop new therapies aimed at blocking tumour progression. We focus our research on tumours that arise upon constitutive Hedgehog signalling pathway activation (Basal Cell Carcinoma and medulloblastoma). To achieve our goal, we study:

1. The role of the different tumour cell populations to cancer progression and response to therapy
2. The contribution of different genetic alterations to cancer progression and response to therapy
3. Development of new therapies aimed at blocking tumour progression